Friday, March 14, 2008

A new, more weight friendly form of Zyprexa?

My CD-rom on psychotropic medications got its original start a few years ago when clinicians were beginning to report that olanzapine (Zyprexa) seemed to be triggering significant weight gain in persons who were using it. To this day, the issue of weight gain and Zyprexa use continues to be a frequently appearing topic in Pub Med.

I just ran across an abstract describing a new formulation of Zyprexa that reportedly does not cause this weight gain. The original formulation was a standard oral tablet; the new formulation is an "orally disintegrating tablet".

This is new information to me, and I have not had the opportunity to see this benefit in action.

If you happen to be reading this post and you HAVE had experience, either similar or to the contrary, I'd love it if you shared it with the rest of us!

Have a great weekend,


Chawla B, Luxton-Andrew H. Long-term weight loss observed with olanzapine orally disintegrating tablets in overweight patients with chronic schizophrenia. A 1 year open-label, prospective trial. Hum Psychopharmacol. 2008 Jan 24

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