Showing posts with label folic acid. Show all posts
Showing posts with label folic acid. Show all posts

Monday, November 24, 2008

I coulda had a V8--er--fish oil pill


There's a part of me that knows that as long as science continues to do things the way it does things, I have journalistic job security.

But the heart inside me really wishes they'd get it so I could trash this blog and head for an isolated Costa Rican beach until I find another pressing issue to blog about.

What I mean by "getting it" is that the reason we're so sick as a culture is not because we're not taking enough medicine, or that we haven't created the perfect medicine. It's because the perfect medicine is sitting right under our noses and we refuse to acknowledge it because it won't give the people who make money off of people being sick...a patent or a respectable profit margin.

Someone who sees things the same way finally got his words into a peer-reviewed journal.

He reports that you can reduce the incidence of heart attack if you get people to take, in combination,
a statin medication,
three different blood pressure medications,
a folic acid supplement, and
an aspirin.

This brave new concoction has been called the "polypill". Yikes! It doesn't take long even for someone who hates math to figure out how many people THAT marketing...um..."treatment" approach employs.

In the words of the author delivering this breaking news,

Unlike the proposed "polypill", EFAs are endogenous molecules present in almost all tissues, have no significant or few side effects, can be taken orally for long periods of time even by pregnant women, lactating mothers, and infants, children, and adults; and have been known to reduce the incidence cardiovascular diseases including stroke.


I propose that a rational combination of omega-3 and omega-6 fatty acids and the co-factors that are necessary for their appropriate action/metabolism is as beneficial as that of the combined use of a statin, thiazide, a beta blocker, and an angiotensin converting enzyme (ACE) inhibitor, folic acid, and aspirin. Furthermore, appropriate combination of omega-3 and omega-6 fatty acids may even show additional benefits in the form of protection from depression, schizophrenia, Alzheimer's disease, and enhances cognitive function; and serve as endogenous anti-inflammatory molecules; and could be administered from childhood for life long.


Sigh...wonder how many pharmaceutical company trash cans that brilliant idea ended up in?

Fortunately, you can decide if you want to support your own health with this idea. It is available over the counter. It's totally up to you.

Das UN. Essential fatty acids and their metabolites could function as endogenous HMG-CoA reductase and ACE enzyme inhibitors, anti-arrhythmic, anti-hypertensive, anti-atherosclerotic, anti-inflammatory, cytoprotective, and cardioprotective molecules. Lipids Health Dis. 2008 Oct 15;7:37.

Monday, March 10, 2008

Folic acid, depression, and Prozac

Folic acid is clearly essential for brain and nervous system health.

When animals are depressed, they have a delayed response to stressful situations. Researchers in this study reported that rats given folic acid who were then forced to swim (a standard test for depression in lab rats, believe it or not!) started swimming sooner than rats who did not receive the supplement.

Folic acid also seemed to promote a synergistic effect with fluoxetine (Prozac), meaning in the presence of folic acid, Prozac was more effective. What this finding has the potential to translate into...is that if you DO need an antidepressant, eating well (or at least taking a multivitamin at the same time)may reduce the dose of the medication you actually need, which in turn reduces the potential for side effects. And side effects are a major reason why people do not maintain compliance with their psychotropic medications.

This seems like it's too simple to be true. But the reality is, when you're depressed, you may not feel like making the effort to eat well. Or, you grab something quick and easy (and likely low in essential vitamins/minerals and high in the wrong kind of fats), which only worsens the depression. If you have time to do only one thing a day that is just for YOU...make it eating well.

Whether it's a Flintstones or a One A Day, consider a multi as an essential part of your mental health bag of tricks!

Brocardo PS, Budni J, Kaster MP, Santos AR, Rodrigues AL. Folic acid administration produces an antidepressant-like effect in mice: Evidence for the involvement of the serotonergic and noradrenergic systems. Neuropharmacology. 2008 Feb;54(2):464-73. Epub 2007 Nov 5.