Friday, February 8, 2008

Topamax and kidney stones

I just ran across an abstract reporting increased uric acid and risk of uric acid stones in users of Topamax. This adds to my list--I'd already found an abstract on the increased risk of calcium phosphate stones. The uric acid research group recommends increasing fluid intake if on Topamax. I would think if you have a history of kidney stones it might be a good idea to discuss with your physician the possibility that another medication may be more appropriate.

Vega D, Maalouf NM, Sakhaee K. Increased propensity for calcium phosphate kidney stones with topiramate use. Expert Opin Drug Saf 2007 Sep;6(5):547-57.
Ko├žer A, Dikici S, Atakay S, Okuyucu E.Serum Uric Acid and Lipid Levels While Taking Topiramate for Migraine. Headache. 2007 Dec 27.

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