Tuesday, September 2, 2008

Why are cats and bipolar disorder showing up in the same blog post?


I volunteer for two different animal rescue groups here in Phoenix. I like to say that when things get tough with humans, I de-stress with the animals. As my friends in these organizations have realized what I do for a living, I've been presented with some interesting opportunities to combine both interests. You may have seen the post about Norm, the abandoned cat who we eventually lost due to consequences of prolonged and severe malnutrition. Thanks to my nutrition colleagues, I was steered toward a refeeding protocol developed by the World Health Organization used with children in third world countries. It's had limited and successful use in animals. I have submitted it to our vet staff for review, with the hopes that the next time an animal in need comes our way, we won't have to go through the emotional stress of losing it.

Last week, my friend Gerda paid me to consult with her about her cat Yani. I know Yani from the Arizona Animal Welfare League, and Gerda is a PhD candidate at Arizona State University. She is so diligent, she has plotted Yani's weight on a white board and kept his intake records over several months so we can problem solve. (Being the animal lover that she is, she put "anonymous" rather than "Yani" next to his assigned color so he wouldn't develop body image issues over being identified as obese!) So all of the medical and nutritional history I have for him makes this like a dream project in a fancy nutritional lab.

Despite Gerda's best efforts and documentation that Yani's food intake is limited, he continues to gain weight. He is, in turn, exhibiting signs and symptoms of depression. No interest in exercise. Extreme interest in food. Interest in food with any kind of environmental stimulation. I find this fascinating, because I used to work in eating disorders. Humans with eating disorders tend to connect all of their eating issues to some kind of psychological issue--an abuse, a trauma, an emotional issue. But here we have a cat, exhibiting the same behaviors and as far as we know he's not been verbally belittled, he's not had his body image assaulted by reading a few too many issues of Elle or Vogue, and he's certainly not being coerced by food ads on television. (Fortunately for Yani, and my Ivy League-ingrained insistence on maintaining proper scientific method, Gerda is more of a PBS than a Desperate Housewives person.)

So we've started a Facebook group and we're trying to figure out why Yani is getting fat when, thanks to a conscientious kitty mom and dad, he is following all the rules.

It seems, we've learned, that cats don't do well with carbohydrates. Many cat foods have carbohydrate fillers. And in reading cat food labels, I've seen supposedly high-protein foods that are high protein because they contain fillers such as corn gluten and soy protein that any self-respecting cat would never choose on his own. Cats are meat eaters. We've switched Yani primarily to meat, tossed the fillers, and we're experimenting with carnitine, a supplement that has been found to help metabolize fat and has actually been studied in cats.

I am particularly interested in what happens with Yani, because it's been my experience that people with mood disorders also seem to have problems with their weight. Some of it is binge eating, I know, but there just seems to be something metabolic that goes with a mood disorder that causes a proneness to gaining weight. It can even often be seen in the body type--solid center of gravity, proneness to gaining weight around the abdomen, skinny legs, in women, a tendency toward bustiness--it's the most common body type I treat in working with mental illness. I just described the apple shaped body type that is defined as a risk factor for metabolic syndrome, if you're not familiar with it. More and more, my observation is being supported in the literature, that people who have metabolic syndrome tend to have this body type...and to be more prone to mood disorders. This long drawn out dissertation is my attempt to be politically correct at saying that sometimes there is a genetic tendency toward a mood disorder, and that can be strongly linked with problems with weight.

When you see the issue manifest in a cat, who isn't subject to the same kind of emotional conditioning as a human, it really points to the fact that some people are, weight and calorie wise, completely different from others.

Researchers recently looked at the medical records of 161 individuals with bipolar disorder. Over three fourths of them were were overweight, and almost half were obese. High triglycerides, high blood pressure, and diabetes were noted at a rate greater than is observed in the general population. Over half met the criteria for metabolic syndrome.

There was a trend toward even greater incidence among individuals whose bipolar disorder was being managed with second generation antipsychotics (for example, Zyprexa). However, the trend existed whether or not those medications were part of the scenario.

My point? There are many psych meds that get blamed for weight gain. The reality is that they may exacerbate a pre-existing tendency toward weight gain, but they do not cause it. That genetic profile may benefit from a certain kind of diet. Just as Yani cannot blame his weight gain on poor social conditioning and must be encouraged to follow a lifestyle that minimizes his identified genetically-based medical risks, so must people with bipolar and other mood disorders. Weight gain is not necessarily an excuse to not take medications. A well-planned diet may help to minimize weight gain, and that is why it can be helpful to work with a nutritionist specializing in mental health, in conjunction with a psychiatrist who understands the complex interactions of mood, weight, and hormone function.

Fiedorowicz JG, Palagummi NM, Forman-Hoffman VL, Miller del D, Haynes WG. Elevated prevalence of obesity, metabolic syndrome, and cardiovascular risk factors in bipolar disorder. Ann Clin Psychiatry. 2008 Jul-Sep;20(3):131-7.

Special note: In order to continue to protect Yani's identity and self-image, the photo above is merely a stock photo of a random cat. The photo is included solely for illustrative purposes and is not intended to belittle or poke fun at any animal whose weight exceeds kitty culturally-accepted norms.


Monday, September 1, 2008

Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains

Today I wanted to share some recent findings about the effects of elevated glucose on a developing baby's nervous system. I often think we start too late when looking for origins of many medical issues. I've learned to start way back in utero when evaluating a situation and trying to sort through what's going on. Here's an example of why that can be important.

A group of chick eggs were injected with glucose. Significant changes were found in the babies that developed from those eggs, including:
--their own hyperglycemia
--elevated oxidative (degenerative) activity in body and brain tissue
--lower body weight
--lower brain weight
There also seems to be lower levels of DHA in babies exposed to hyperglycemia. This may be due to the elevated oxidative activity destroying any DHA that might be there.

You're likely aware that taking folate is pretty much an across the board recommendation to pregnant women. In this study, hyperglycemia seemed to induce a level of oxidation/inflammation that was not significantly helped with a folate supplement.

Bottom line, it's important to eat well not just to avoid weight gain or to keep your blood sugar low to keep your doctor and dietitian happy, but because your baby's brain and body depend on you to do so.

Most of my clients express surprise that healthy eating includes as many tasty foods as it does. So before you write off a visit to the dietitian because you're afraid of what you WON'T be able to eat, consider that it may be your ticket to freedom and guilt relief to work with someone who can introduce you to the many foods that will BENEFIT you and baby!

Cole NW, Weaver KR, Walcher BN, Adams ZF, Miller RR Jr. Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains. Comp Biochem Physiol B Biochem Mol Biol. 2008 Jul;150(3):338-43.

Wednesday, August 27, 2008

It starts with Mom


It's so good to be back! I love my morning routine, which involves getting up, checking my email, giving milk to the cats, working out, fixing my coffee, then settling in for an hour or two of reading research that I end up sharing in my blogs. It's been about a month since I've been able to indulge that routine, and I am so glad to be back in the groove! Today I'm going to share some more research about what happens to the brains of developing babies whose mothers don't get enough omega-3 fatty acids. This time we're looking at linolenic acid (ALA), which comes primarily from flaxseed oil and nuts. This omega-3 appears to be important for the metabolism of the neurotransmitter dopamine.

When ALA is deficient, in the hippocampus, levels of enzymes that help to create dopamine from its building blocks drop. There is also a reduction in the number of vesicles that transport the finished product, dopamine, to where it can be released and used as a neurotransmitter. As a result, dopamine levels may back up in the neuron, which the researchers in this study propose may potentially damage the terminals in charge of processing dopamine.

In the cortex and striatum, under these same conditions, there is an increase in dopamine receptor levels. These same researchers propose that this is some sort of compensatory mechanism that allows cells "downstream" from the problem to maximize their ability to capture and use what dopamine is available.

Dopamine is important for impulse control. It is also the focus of much Parkinson's disease research. The D2 receptor mentioned in this study is especially important for managing weight, carbohydrate cravings, and addictions.

Could it be that many of the chronic problems medical professionals deal with and that we as people live with...have their origin before we're even born?

I've been saying for years that the population that needs the focus of our preventive nutrition and medical education is women of childbearing age. If we don't catch problems then, and if we focus on telling them what NOT to eat instead of helping them best eat for two...well, unfortunately, it may end up being job security for anyone whose work uniform includes a lab coat.

Kuperstein F, Eilam R, Yavin E. Altered expression of key dopaminergic regulatory proteins in the postnatal brain following perinatal n-3 fatty acid dietary deficiency. J Neurochem. 2008 Jul;106(2):662-71.

Sunday, August 17, 2008

Great news for you readers struggling with infertility!


I'm going to be a little less active for about a week here, but it's for an important reason that will hopefully serve at least a few of you who regularly visit my blog!

For the past few years I've been training colleagues around the country in some of the practical aspects of using nutrition to help with mental health problems. One of the areas where these issues abound is in fertility treatment. So I've been actively using the same concepts that work for anxiety and depression to help with infertility. The colleagues I've been working with, as we've gained an understanding of how it all fits together, have been reporting some wonderful success stories in clients who had been told they might never have a child of their own.

As we've grown as a network, we've gained the attention of sponsors, and one of those sponsors, Nutrabella, approached me about collaborating with them to contribute to a fertility report that will be appearing in East Coast newspapers this coming Friday--the Washington Post, Wall Street Journal, and Boston Globe, to name a few. Another sponsor, SGJ Consulting, contributed to the project as well. It's been a great team to work with from start to finish!

That kind of opportunity has the potential to reach quite a few people (2.1 million is what has been projected)! So I've been busy making sure we're ready to handle the traffic and that everyone who's been going through my training is ready to take referrals.

If you know of anyone who is struggling with infertility, please tell them we have several resources:
(1) our network's blog,
(2) individual consultations, and
(3) Fertile Intentions (TM), our new couples infertility spa day experience, in Marina del Rey, California.

This is such a great audience with whom to share the message that there are many options outside of medication for helping with stress-related problems.

I'll be back in about a week, hopefully with some exciting updates, and definitely with more comments on nutrition and mental health.

Have a wonderful rest of August in the meantime!

Friday, August 15, 2008

A little about vitamins...and a lot about food and mood


My friend Diane Whelan and I toured a vitamin factory yesterday. Was that ever interesting! I guess you just assume all those pills show up in all those bottles on their own. I learned so much about what it takes to grow the herbs, extract the active ingredients...even how much it takes to be an international business and sell different formulations to different countries while being in compliance with labeling regulations and varying cultural nutritional needs.

At one point our guide hand-pressed me a personal supplement the old-fashioned way.

Diane works with a product line called Nutrilite. The products are very high quality, and what really struck me as we toured the factory was how proud the employees were of their work.

You can learn more about this product line at this link: http://www.afterthediet.com/whyvitamins.htm

I receive no commission from Nutrilite for sharing this information. I simply like to share good information and products when I do see them.

Below is some great information about food and mood from Nutrilite that you also may enjoy.

You and Your Mood: What’s Food Got to Do with It?
Duke Johnson, M.D.
Medical Director, Nutrilite Center for Optimal Health

Do you head straight for the ice cream after an especially hard day at work? It seems like a no-brainer that your mood affects your food choices. But did you know that food can also affect your mood? There are foods that can give you a boost when you need one.

The food-mood connection
It starts with chemicals in your brain, called neurotransmitters. They act like a one-way command center, telling your brain cells what message to pass on to all the other cells. Two neurotransmitters always send a “pay attention, stay alert” message, while another one always sends a “calm down, relax” message.

Now, consider this: If your diet doesn’t include the right nutrients, your brain won’t make enough neurotransmitters to send messages at optimum levels. And if you eat (or don’t eat) specific nutrients, your brain selectively makes certain neurotransmitters but not others.

Generally speaking, the following nutrients all affect neurotransmitter production:

Proteins.
Carbohydrates.
Vitamins.
Minerals.
For example, if you don’t consume enough food with the right amount of B vitamins, vitamin C, selenium, and magnesium, your body won’t produce or store enough of these critical chemical messengers.

And that’s how the foods you eat (or don’t eat) affect your mood, energy levels, stress, and sleep habits.

And in case you want to know their names, the “high-alert” neurotransmitters are dopamine and norepinephrine. And serotonin has a calming, anxiety-reducing effect.

How to say it:
(emphasize the syllable in bold):

Neurotransmitters: Nurr-oh-trans-mitters.
Dopamine: Dope-a-mean.
Norepinephrine: Nor-eppa-neff-rinn.
Serotonin: Ser-oh-tone-in.
Feeling down?
Eat a small amount of carbs, like whole-grain cereal, whole-wheat pasta, or yogurt with fruit. That stimulates serotonin production, and relaxation and calm will follow.

Want more energy?
But if you’re gearing up for an exam or an interview, you should eat some lean protein with healthy carbs. That will trigger dopamine and norepinephrine, to get your mental juices flowing.

Nutrient
Food
Results
How

Lean protein
Meat, low-fat dairy, and eggs
Increases your alertness and concentration
Increased production and activity of dopamine and norepinephrine

Healthy carbohydrates
Brown rice, plain oatmeal, whole-grain cereals, and fresh fruit
Improves your mood, curbs your food cravings, and helps you sleep
Increased production and activity of serotonin

Omega-3 fats
Salmon, tuna, sardines, anchovies walnuts, and flaxseed

Increased production and activity of serotonin


Brain drainers and brain boosters
Be careful about grabbing chips, crackers, or fast food when you’re feeling down or stressed. It definitely can make you feel better, because processed foods high in sugar and saturated fat give you a burst of energy. But not too much later, you’ll crash and feel irritable and anxious.

And then, to feel better, it’s natural to return to the food and drink that gave you energy … but it’s easy to see where that leads – more sugar and more unhealthy fats, another boost and another crash.

Break this cycle and feel better – in a healthier, more lasting way, by eating these brain boosters, instead:

Brain drainers
Brain boosters

Coffee and a doughnut for breakfast
Oatmeal topped with berries, and a hard-boiled egg

Hamburger, fries, and soda for lunch
Turkey sandwich on whole-grain bread and veggies

Frozen fish nuggets and tater tots for dinner
Grilled salmon, broccoli, brown rice, and a green salad


Comfort foods
Sometimes the only food that will do is the meatloaf and mashed potatoes Mom used to make when you were a kid. Or maybe it’s tomato soup and grilled cheese sandwiches. The strong emotional connection of these comfort foods stimulates release of the “feel good” neurotransmitters.

And to balance out the comfort food, up the nutritional quality. If you want a cookie, make it oatmeal raisin or fruit filled. Buy lower-fat ice cream or single-serve popsicles. Throw some veggies on that pizza.

What you drink matters, too
Do you reach for a cup of java or cola first thing in the morning or a glass of wine in the evening? Caffeine and alcohol can improve your mood, but too much of a good thing can have not-so-good consequences. Three hundred milligrams of caffeine – roughly what you get from three cups of brewed coffee – can increase your alertness and concentration. But more than 300 mg can make you nervous and jittery.

Alcohol has its pros and cons, too. Two drinks a day for men and one for women is linked to a lower risk of heart disease, but more than that may lead to weight gain, difficulty sleeping, and decreased powers of concentration. Too much alcohol also makes it easier to choose foods that don’t support a good mood.

Eat well to feel good
Feed your brain the best food you can! Choose a balanced diet of lean protein, healthy carbs, and omega-3 fats. Make sure to take a multivitamin that delivers the right blend of vitamins, minerals, and phytonutrients. Add regular exercise, enough sleep, and decisions that fit your lifestyle priorities. And you’ve got a no-brainer recipe for mastering your mood.

Monday, August 11, 2008

So tell me again....WHY are we telling pregnant women to avoid eating fish?


This is one of those issues that simply drives me crazy. The Food and Drug Administration, several years ago, because of mercury content, identified four fish that might be harmful to consume during pregnancy. Those four fish were king mackerel, tilefish, swordfish, and shark.

For the recored, in 26 years of doing this work, I have yet to EVER have ANYONE at ANY point in their life tell me in a diet recall that they eat mackerel (too fishy), shark (eeeuuw!!!), or tilefish (what the heck is a tilefish?). Swordfish is a rare item that comes up.

Let's count those again. Four fish. Mackerel. Shark. Tilefish. Swordfish.

In the time that this warning has come out, consumption of ALL fish has decreased, by about one sixth (17%).

Why have we overgeneralized? Because scary headlines are what sell newspapers and news broadcasts. And when newspapers sell and news shows are watched, newspapers and television stations make more money from advertising.

Did you know, that the losses associated with this preventative measure may outweigh the benefits? According to the Harvard Review, if pregnant women were to eat the same amount of fish they normally do, but replaced fish high in mercury with fish low in mercury, cognitive development benefits could be achieved with virtually no nutritional losses. When those cognitive development benefits are taken into consideration, if those women were to cut their fish consumption by one-sixth, exactly what has happened, the nutritional benefit derived drops by 80%.

A new study suggests that omega-3 deficiency during pregnancy may have effects years later. A group of researchers who had reported that supplementing pregnant and lactating women with omega-3 fatty acids during pregnancy resulted in higher IQ scores in their children 4 years after birth, retested the same children at 7 years. The women in this study either took 10 ml of cod liver oil or corn oil from the 18th week of pregnancy until 3 months after their babies were born. Mothers with high levels of plasma ALA and DHA (two omega-3 fatty acids) had children who better learned information, organized it, and later used it in practical situations.

Again...'splain me why we're telling pregnant women to be afraid of fish?

http://www.hno.harvard.edu/gazette/2005/10.20/26-merc.html

Helland IB, Smith L, Blomén B, Saarem K, Saugstad OD, Drevon CA. Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics. 2008 Aug;122(2):e472-9.

Wednesday, August 6, 2008

Carnitine supplementation enhances Depakote activity

For the last few months I've been reading carnitine research (there's a boatload of it and it's completely kept me out of trouble!)

It is pretty well documented that people taking valproic acid (Depakote) have a problem maintaining carnitine levels. To the point where, after doing this research, I have no problem saying that anyone on Depakote should automatically be placed on L-carnitine as well.

Anyway, I just found an article reporting that carnitine supplementation in conjunction with Depakote use enhanced the levels of Depakote in the brain. In other words, if you use carnitine while using Depakote, you won't need as much Depakote. And if you're not using as much Depakote, you're not as likely to experience the side effects that make people not want to comply with the regimen, such as weight gain, infertility, acne, yadayadayada.

Monika's Bottom Line
Doctors should have a carnitine chip inserted in the medication-prescribing region of the brain that does not allow them to script this med without also scripting this supplement.

Sakemi K, Takada G. Effect of carnitine on valproic acid concentrations in serum, brain, and liver. Pediatr Neurol. 1998 Apr;18(4):331-3.